Efficacy and safety of mirabegron combined with solifenacin for catheter related bladder discomfort in patients undergoing transurethral resection of the prostate:A prospective case-control study
Efficacy and safety of mirabegron combined with solifenacin for catheter related bladder discomfort in patients undergoing transurethral resection of the prostate:A prospective case-control study
Objective To investigate the safety and efficacy of mirabegron combined with solifenacin in the treatment of CRBD after TURP.Methods A total of 108 patients with BPH who underwent TURP were randomly divided into three groups,36 cases in each group.Patients in M+S group were given oral mirabegron 50 mg/d combined with solifenacin 5 mg/d from one day before surgery;S group was given solifenacin 5 mg/d;C group received surgical treatment only.Patients with more than moderate degree of CRBD after operation were scored,and those who met the indications were given intravenous spasmodic and analgesic treatment.The occurrence of CRBD in each group at the 1st,3rd and 5th day after surgery and the amount of intrave-nous fluids within the 5th day after surgery were recorded,the time of continuous catheter washout and adverse drug reactions were also recorded.Results A total of 106 patients were included in the final analysis.On postoperative day 1,the probability of more than moderate CRBD was not significantly different between the M+S and S groups(P＞0.05),in addition,the inci-dence of overall CRBD,the incidence of more than moderate CRBD,and the amount of intravenous fluids in the M+S group were significantly less than those in the S and C groups at any time point(P＜0.05).Compared with C group,S group did not reduce the overall incidence of CRBD(P＞0.05),but the incidence of CRBD above moderate degree and the amount of intrave-nous infusion were better than those in C group(P＜0.05).There was no difference in heart rate,systolic blood pressure and diastolic blood pressure between the three groups before surgery and 1,3 and 5 days after surgery(P＞0.05).There was no difference in the incidence of dry mouth,constipation,too(P＞0.05).One additional case of rash was reported in the M+S group.Conclusion Mirabegron combined with solifenacin can reduce the incidence of CRBD after TURP,reduce the intravenous use of spasmolytics,and has a more significant effect than solifenacin alone without increasing adverse drug reactions.
mirabegron/solifenacin/transurethral resection of the prostate/catheter related bladder discomfort/β3 adre-noceptor agonist/amount of intravenous fluids/muscarinic receptor antagonists
维普
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