Construction of BPQDS@TNTS drug carrier and its sustained release properties
Objective To construct a dual-drug-loaded composite drug carrier loaded with alendronate and gentamicin on orthopaedic titanium plate.Methods Nanotube arrays(TNTs)were prepared on the surface of TiO2 by anodic oxidation,then dynamically adsorbed sodium alendronate and were filled with gentamicin sulfate-loaded BP quantum dots(BPQDs).The tube mouth was encapsulated with nutmeg.The tube was characterized by X-ray diffraction and transmission electron microscopy.The sustained release rate of alendronate and gentamicin loaded on the tube was determined by chromatography.Results X-ray diffraction showed that the BPQDS@TNTS drug carrier had characteristic diffraction peaks of BP and TNTs.Transmission elec-tron microscopy showed that nutmeg had successfully sealed TNTs,the alendronate and sulphate gentamicin in TiO2 nanotubes and BPQDs carriers were almost completely released within 72 hours,while the alendronate and sulphate gentamicin in BPQDs@TNTs carriers were almost completely released within 96 hours.Conclusion BPQDs@TNTs drug carrier can successfully carry alendronate and gentamicin sulfate,and has better sustained-release efficacy in body fluids.
万方数据
维普
