Expression and clinical analysis of secretory granin Ⅱ in colorectal neuroen-docrine tumors
Objective To investigate the expression and diagnostic value of secretogranin Ⅱ(SGⅡ)in colorectal neuro-endocrine tumors(CRNETs).Methods The expression of SG Ⅱ、Syn、CD56、CgA and Ki-67 were detected using immuno-histochemical EnVision two-step method in 165 neuroendocrine neoplasms(NENs)and 136 non-neuroendocrine neoplasms.Re-sults 1)The positive rates of SGⅡ in CRNETs G1,G2,G3 and NEC were 97.2％(104/107),100％(40/40),100％(5/5),69.2％(9/13),respectively.Higher than the positive rate of non-NENs(1.47％,7/136)(P＜0.05);2)The sensitivity of SGⅡ in CRNETs was 95.8％(158/165),which was similar to Syn(98.8％(163/165),higher than that of CD56(84.2％(139/165)and CgA(33.9％).3)Tumor diameter,invasion depth,vascular invasion,nerve invasion and lymph node metastasis were negatively correlated with SⅡ expression and positively correlated with Ki-67 expression,with statistical signifi-cance(P＜0.05),while CgA was negatively correlated with the above tumor traits,with no statistical significance(P＞0.05).Conclusion SGⅡ is highly expressed in colorectal neuroendocrine tumors,which is a reliable marker for the differential diagno-sis of CRNETs.Its expression is negatively correlated with tumor diameter,invasion depth,vascular invasion,nerve invasion and lymph node metastasis.
万方数据
维普
