Changes of regulatory T Cells in acute myeloid leukemia and its prognostic signifi-cance
Objective To investigate the changes of CD4+Foxp3+regulatory T cells(Tregs)in acute myeloid leukemia(AML)and its relationship with the prognosis of AML.Methods Flow cytometry was used to detect the percentages of Tregs among CD4+T cells in peripheral blood of newly diagnosed AML patients and healthy controls.AML patients were divided into good prognosis group,medium prognosis group and poor prognosis group by cytogentic karyotype.Then,the difference in the percentages of Tregs among CD4+T cells among each group was analyzed to explore the potential prognostic significance of Tregs in AML.Results The percentages of circulating CD4+Foxp3+Tregs in AML patients was significantly higher than that of healthy controls(6.171％±0.292％vs.2.437％±0.144％,P＜0.000 1).There was no significant difference in the per-centages of Tregs among CD4+T cells among different subtypes of AML(P＞0.05).We found that the ratio of circulating Tregs in the poor prognosis group was significantly higher than that in the better prognosis group(7.316％±0.592％vs.5.179％±0.429％).Conclusion The percentages of CD4+Foxp3+Tregs among CD4+T cells are significantly increased in pa-tients with AML,which has certain significance for prognostic evaluation.
acute myeloid leukemiaregulatory T cellsflow cytometryprognosis
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