Non-invasive pressure-strain loop assessment of myocardial work in patients with coronary heart disease complicated with hyperuricemia
Objective To evaluate myocardial work in patients with coronary heart disease(CHD)complicated with hy-peruricemia using non-invasive pressure-strain loops(PSL).Methods A retrospective analysis was conducted on 119 patients with CHD who were admitted to the cardiology department of our hospital and diagnosed with digital subtraction angiography(DSA)from December 2021 to December 2022.The baseline serum uric acid levels of the patients were recorded,and they were divided into a high uric acid group(n=38)and a normal uric acid group(n=81)based on their serum uric acid levels.Both groups underwent routine echocardiography and utilized the EchoPAC software to construct left ventricle PSL by inputting blood pressure values.Myocardial work parameters were obtained,including global work index(GWI),global constructive work(GCW),global wasted work(GWW),and global work efficiency(GWE).GWE=GCW/(GCW+GWW).The differences in these parameters between the groups,as well as their correlation and regression with serum uric acid,were compared.Results There were statistically significant differences in GWI and GCW between the two groups(both P＜0.05).Both GWI and GCW were reduced in the high uric acid group.Pearson correlation analysis showed that GWI and GCW were negatively correlated with serum uric acid values(r=-0.255,-0.242,P＜0.05).Linear regression analysis showed a linear correlation between left ventricular myocardial work values and serum uric acid levels in patients with CHD.Conclusion Non-invasive pressure-strain loops can quantify the myocardial damage caused by high uric acid levels in patients with CHD,thus providing clinical guidance.
pressure-strain loopcoronary artery diseasehyperuricemiamyocardial work
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