Effect of Citri Reticulatae Pericarpium extracts on the learning and memory func-tion of APP/PS-1 double transgenic Alzheimer's disease mice
Objective To explore the effect of Citri Reticulatae Pericarpium extracts on the learning and memory ability of APP/PS-1 double transgenic Alzheimer's disease(AD)mice.Methods A total of 16 APP/PS-1 double transgenic AD mice were selected.They were randomly divided into model control group and test group(Citri Reticulatae Pericarpium extracts,986 mg/kg),eight animals per group,another eight C57 mice were selected as the normal control group.Normal control group and model control group were respectively given the same amount of normal saline,the test group was given normal saline solution of Citri Reticulatae Pericarpium extracts.The volume of intragastric administration was 10 mL/kg once a day for 18 consecutive days.From day 11 to day 16,the positioning navigation experiment and space exploration experiment of Morris water maze were carried out.From the 17th to the 18th day,5 min dark avoidance test was carried on.Results In the Morris water maze experi-ment,compared with the normal control group,the incubation period of the model control group was increased on the 2nd,3rd and 5th day of positioning navigation(P＜0.05).Compared with the model control group,the incubation period of the test group on day 5 was decreased(P＜0.05).During the space exploration phase,there was no statistically significant difference(P＞0.05)in the target quadrant distance percentage,time percentage,and platform crossing frequency among the groups.There were no significant differences in error latency,error times and error rate among all groups in the dark avoidance experi-ment(P＞0.05).Conclusion Citri Reticulatae Pericarpium extracts can improve the spatial learning and memory ability of APP/PS-1 double transgenic AD mice.
Citri Reticulatae Pericarpium extractsAPP/PS-1 double transgenic AD miceMorris water maze experimentdark avoidance experiment
万方数据
维普
