Causal effects of benign prostatic hyperplasia and bladder cancer in male popula-tion:a two-sample Mendelian randomization study
Objective To explore the causal effect of benign prostatic hyperplasia(BPH)on the risk of bladder cancer(BCa)in the male population using the two-sample Mendelian randomization(MR).Methods Genome-wide association study data for BPH exposure data(n=172 961)from the FinnGen R9 database and BCa outcome data(n=167 020)from the UK Biobank were obtained.Significant single nucleotide polymorphism loci were selected as instrumental variables after screening.Heterogeneity tests were conducted using the MR-PRESSO test,MR Egger method,and the inverse variance-weighted(IVW)method to remove outliers.MR analyses were performed using the MR Egger method,weighted median estimate,and IVW method to assess the causal relationship.The sensitivity and pleiotropy of the results were tested using MR Egger regression test and leave-one-out method to ensure reliability of the analysis.Results In this MR analysis,no causal relationship was found be-tween BPH and the risk of BCa in the male population using the MR Egger method,weighted median estimate,and IVW me-thod.No significant heterogeneity or pleiotropy was detected,and sensitivity analysis did not reveal any results contrary to the hypothesis.Conclusion Mendelian randomization study does not support a causal effect of benign prostatic hyperplasia on the incidence of bladder cancer in the male population.
万方数据
维普
