Objective To explore the application value of P3b component of event-related potentials in the diagnosis of cognitive impairment of Parkinson's disease(PD)patients.Methods The difference in P3b indicators between PD group and healthy control group was compared,and the dependence relationship of P3b indicator on clinical data and cognitive impairment in the PD group was evaluated.Results The P3b latency of Parkinson's disease dementia(PDD)group was longer than that of PD mild cognitive impairment(PD-MCI)group(P＜0.05),and significantly longer than that of the healthy control group and PD normal cognition(PD-CN)group(P＜0.01).The P3b latency of the PD group was negatively correlated with the Montreal cognitive assessment(MoCA)score(r=-0.506,P＜0.05),visuospatial and executive functions and delayed recall had nega-tive impact on the P3b latency(t=-4.775,P＜0.01;t=-2.186,P＜0.05).The P3b latency in the PD group was positively correlated with age,Hoehn Yahr grading,and UPDRS-Ⅲ score(r=0.191,P＜0.05;r=0.262,P＜0.01;r=0.218,P＜0.05),and negatively correlated with years of education(r=-0.340,P＜0.01);The P3b latency in the PD group was not sig-nificantly correlated with gender and the course of Parkinson's disease(r=0.041,P＞0.05;r=0.084,P＞0.05).Conclusion The more severe the cognitive impairment,the longer the P3b latency.P3b latency can serve as a quantitative indicator of PD cognitive impairment,which is meaningful for early identification of PD cognitive impairment.
维普
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