Pathogen characteristics and drug resistance analysis of clinical infections in Fujian province
Objective To explore the distribution characteristics of clinically isolated pathogens in Fujian Province and their resistance to commonly used antibiotics,and to provide reference for rational drug use in clinical practice.Methods Anti-microbial susceptibility tests on clinically isolated strains according to a unified protocol were conducted in sixty hospitals in the province,and data were analyzed using WHONET5.6 software.Results After removing duplicate strains,55 995 Gram posi-tive bacteria(30.3％)and 128 804 Gram negative bacteria(69.7％)were detected,mainly from sputum,urine,blood,etc.The top 3 Gram positive bacteria detection rates lied in staphylococcus aureus,enterococcus faecalis,streptococcus pneumoniae.The detection rates of MRSA and MRCNS were 27.3％and 73.9％,respectively.No vancomycin,teicoplanin,or linezolid re-sistant staphylococcus were found.The top 3 Gram negative bacteria detection rates lied in escherichia coli,klebsiella pneumoni-ae,pseudomonas aeruginosa.The resistance rate of escherichia coli to imipenem was 1.1％,while the resistance rates to cefo-taxime and levofloxacin were 46.9％and 45.9％,respectively.The resistance rate of Klebsiella pneumoniae to imipenem was 11.2％;The resistance rate of acinetobacter baumannii to imipenem was 50.5％,and the resistance rate to other antibiotics was mostly over 40％.The resistance rate of pseudomonas aeruginosa to imipenem was 17.0％,and it also maintained high sensitivi-ty to most other drugs.Conclusion The main pathogens causing clinical infections in Fujian province are Escherichia coli,kleb-siella pneumoniae,and staphylococcus,etc.Some pathogens have severe drug resistance and should be used correctly and rea-sonably in clinical practice.
distribution of pathogenic bacteriaantibacterial drugsdrug resistancebacterial resistance surveillance
万方数据
维普
