Effect of Huazhuo Sanjie Chubi Decoction and Huazhuo Sanjie Chubi Decoction Combined with Allopurinol in Treatment of Chronic Gouty Arthritis
Objective:To compare and observe the curative effect of Huazhuo Sanjie Chubi Decoction(HSCD),allopurinol and their combination in the treatment of chronic gouty arthritis(CGA).Methods:A total of 169 male patients with CGA who were admitted to the Third People's Hospital Affiliated to Fujian University of Traditional Chinese Medicine and the Guoyitang of Fujian University of Traditional Chinese Medicine from July 2021 to March 2023 were selected and divided into the western medicine group(56 cases),traditional Chinese medicine(TCM)group(56 cases)and combined treatment group(57 cases)according to random num-ber table method.The western medicine group took allopurinol orally,the TCM group was given oral treatment of HSCD,and the combined treatment group was treated with the above two.The course of treatment was 8 weeks.During treatment,6 cases fell off in the western medicine group,4 cases fell off in the TCM group and 7 cases fell off in the combined treatment group.Finally,152 cas-es were completed in the study,50 cases in the western medicine group,52 cases in the TCM group and 50 cases in the combined treatment group.The levels of serum uric acid(UA),creatinine(Cr)and erythrocyte sedimentation rate(ESR)before treatment and 4 weeks and 8 weeks after treatment;the total score of TCM syndromes,and the single TCM syndrome scores(including joint swelling,joint pain,adverse flexion and extension)before and after treatment in the 3 groups were counted.The number of gout attacks in the 3 groups during treatment was observed,and the efficacy and adverse reactions were compared.Results:Compared with those before treatment,UA,Cr,and ESR in 3 groups decreased after 4 weeks and 8 weeks of treatment,the difference was statis-tically significant(P<0.05);the total score of TCM syndromes and the single TCM syndrome scores decreased between the TCM group and the combined group(P<0.05).After 4 weeks of treatment,The UA in TCM group was higher while the ESR was lower than that in western medicine group(P<0.05).After treatment,compared with the western medicine group,the total score of TCM syndrome,and the single TCM syndrome scores and the number of gout attacks during treatment in the the TCM group and the combined group were lower,with statistical significance(P<0.05).Conclusion:HSCD and its combination with allopurinol can sig-nificantly reduce the level of UA,Cr and ESR in CGA patients,improve TCM syndrome scores and reduce the number of gout attacks during treatment.HSCD and its combination with allopurinol treatment could be better than allopurinol treatment in improving joint swelling,joint pain,adverse flexion and extension,and reducing the frequency of gout attacks during treatment.
chronic gouty arthritisHuazhuo Sanjie Chubi Decoctionspleen deficiency and dampnessphlegm and stasis binding syndrome
万方数据
维普
