A base-catalyzed 1,6-conjugate addition of p-QMs for the preparation of diaryl methyl ethers (thioether) has been developed with 37％ to 95％ yields,which realized the solvolysis reaction between p-QMs and alcohol (thiophenol) under the catalysis of 20％ NaOH. The method features easy operation,mild condition and good functional tolerance. A gram scale experiment was examined in 80％ yield,which provides possibility for potential application and transformation in later stage.
关键词
碱催化/对亚甲基苯醌/1,6-共轭加成/醇/二芳基甲基醚
Key words
Base catalyzed/p-QMs/1,6-Conjugate addition/Alcohol/Diaryl methyl ethers
维普
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