首页|Systematical explorations of forensic feature and population genetic diversity of the Chinese Mongolian group from northwest China via a self-constructed InDei panel
Systematical explorations of forensic feature and population genetic diversity of the Chinese Mongolian group from northwest China via a self-constructed InDei panel
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国家科技期刊平台
NETL
NSTL
万方数据
This study aimed to investigate the genetic polymorphisms and population characteristics of Chinese Mongolian group from northwest China(NCM)through a self-developed panel including 43 autosomal insertion/deletion(A-InDel)polymorphism genetic markers.Herein,288 unrelated healthy individuals from the NCM group were employed to obtain the genetic data of 43 A-InDels through multiplex PCR amplification and InDel genotyping using capillary electrophoresis platform.In addition,multiplex population genetic analyses were performed between the NCM group and 27 reference populations.There were no deviations at 43 loci from Hardy-Weinberg equilibrium in the NCM group.The observed heterozygosity(Ho)values ranged from 0.312 8 to 0.559 2,and the combined power of discrimination(CPD)and cumulative probability of exclusion(CPE)values in the NCM group were 0.999999999999 999 99877 and 0.999814,respectively.The forensic parameter values indicated that this panel was polymorphic and informative in the NCM group and could be used as an effective tool for forensic personal identification.Furthermore,the results of pairwise genetic distances,principal component analysis,multidimensional scaling analysis,phylogenetic tree construction,and admixture analysis among the NCM group and 27 reference populations revealed that there were closer genetic relationships between the NCM group and East Asian populations,especially Chinese Hui group(CHH)from the northwest China,which is consistent with the geographical location.These present findings contributed to the ongoing genetic explorations and insights into the genetic architecture of the NCM group.
国家科技期刊平台
NSTL
万方数据
