首页|Forensic efficiency and population genetic construction of Guizhou Gelao minority from Southwest China revealed by a panel of 23 autosomal STR loci

Forensic efficiency and population genetic construction of Guizhou Gelao minority from Southwest China revealed by a panel of 23 autosomal STR loci

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  • 国家科技期刊平台
  • NETL
  • NSTL
  • 万方数据
Short tandem repeats(STRs)are the most common genetic markers in forensic and human population genetics due to their high polymorphism,rapid detection,and reliable genotyping.To adapt the rapid growth of forensic DNA database and solve problems in disputed cases,a panel of 23 autosomal STR loci with high discriminating ability was constructed recently.The Tai-Kadai-speaking Gelao is the most ancient indigenous minority in Guizhou province,however,the forensic efficiency and population genetic structure remain poorly explored.Here,490 Guizhou Gelao individuals from Southwest China were genotyped with the panel of 23 STRs using the Huaxia Platinum Kit.A total of 265 alleles were screened.The combined discrimination power and the combined probability of paternity were 0.9999 and 0.9999,respectively.This indicated the 23 loci had higher discrimination power in Guizhou Gelao and could be applied to forensic practice.Comprehensive population structures with reference populations from China and abroad using the neighbour-joining phylogenetic tree(N-J tree),multidimensional scaling,principal component analysis and heatmap demonstrated that Guizhou Gelao was genetically closer to Guizhou Han than other populations.Moreover,our results showed that a complex phylogenetic model was influenced by ethnic,geographic,and linguistic factors.

short tandem repeatsGuizhou Gelaogenetic polymorphismspopulation structure

Siyu Chai、Shuhua Li、Ruxin Zhu、Li Luo、Kaiqin Chen、Yinlei Lei、Weihong Wan、Xijie Hu、Shiquan Liu、Pengyu Chen

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Shanghai Key Lab of Forensic Medicine,Key Lab of Forensic Science,Ministry of Justice,China(Academy of Forensic Science),Shanghai,China

Center of Forensic Expertise,Affiliated hospital of Zunyi Medical University,Zunyi,China

Key Laboratory of Cell Engineering of Guizhou Province,Clinical Stem Cell Research Institute,Affiliated Hospital of Zunyi Medical University,Zunyi,China

Collaborative Innovation Center of Chinese Ministry of Education,Zunyi Medical University,Zunyi,China

School of forensic medicine,Shanxi Medical University,Taiyuan,China

Institute of Evidence Law and Forensic Science,China University of Political Science and Law,Beijing,China

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2024

10.1093/fsr/owad058

法庭科学研究(英文)
司法鉴定科学研究院

法庭科学研究(英文)

ISSN：2096-1790
年,卷(期)：2024.9(2)