首页|Y-STR analysis of highly degraded DNA from skeletal remains over 70 years old

Y-STR analysis of highly degraded DNA from skeletal remains over 70 years old

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  • 国家科技期刊平台
  • NETL
  • NSTL
  • 万方数据
The goal of the following study is to clarify whether the skeletal remains over 70 years old from missing persons and their alleged relatives shared identical Y-STR loci.Nowadays,advances in ancient DNA extraction techniques and approaches of using multiple different Y-STRs have significantly increased the possibility of obtaining DNA profiles from highly degraded skeletal remains.Given the ages and conditions of the skeletal remains,ancient DNA extraction methods can be used to maximize the probability of DNA recovery.Considering that information about distant relatives is more relevant for long-term missing persons and alleged family members are male,Y-STR loci analysis is considered the most appropriate and informative approach for determining paternal lineage relationship.In this study,Y-STR genotypes obtained from these alleged relatives were identical to each other and to the alleles of missing persons'consensus profiles at more than 22 loci examined,whilst not being found in Y-STR population database from Y-Chromosome STR Haplotype Reference Database.Therefore,Missing Person No.7 and Missing Person No.18 have a patrilineal relationship with reference samples from Family1 and Family2,respectively.In addition,the fact that Y-STR haplotypes obtained from skeletal remains of missing persons and reference samples are not found in the Han Chinese people from East Asian demonstrates its rarity and further supports a paternal lineage relationship amongst them.

Y-STR analysisskeletal remainshighly degraded DNAforensic genetics

Jiashuo Zhang、Xuebo Li、Liangliang Li、Anqi Chen、Suhua Zhang

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Research Center for Chinese Frontier Archaeology of Jilin University,Changchun,China

Key Laboratory of Evidence Identification in Universities of Shandong Province,Shandong University of Political Science and Law,Jinan,China

Institute of Forensic Science,Shandong University of Political Science and Law,Jinan,China

Institute of Forensic Science,Fudan University,Shanghai,China

Department of Forensic Medicine,School of Basic Medical Sciences,Fudan University,Shanghai,China

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2024

10.1093/fsr/owae020

法庭科学研究(英文)
司法鉴定科学研究院

法庭科学研究(英文)

ISSN：2096-1790
年,卷(期)：2024.9(2)