Research Progress of Fluorescence Detection Response Mechanism of Organic Small Molecular Probes to Peroxynitrite Anion
Peroxynitrite anion(ONOO‒)is one of the most active species of reactive oxygen species(ROS)and reactive nitrogen species(RNS).As an important physiologically active molecule,the abnormal expression of ONOO‒will damage the protein and DNA in cells,leading to inflammation and other serious diseases in vivo.In recent years,fluorescence detection technology has been used to realize rapid and sensitive monitoring of bioactive molecules,and imaging tools have been used to conduct high-resolution tracing.Therefore,many organic small molecule fluorescent probes have been developed to detect ONOO‒.In this paper,the recent research progresses of ONOO‒ fluorescence detection methods based on intramolecular charge transfer(ICT),photoinduced electron transfer(PET),fluorescence resonance energy transfer(FRET),excited state intramolecular charge transfer(ESIPT)and other fluorescence response mechanisms were reviewed.
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