Direct Electrochemical Glucose Sensing Platform Based on Carbon Dots and Metal-Organic Framework Composite Materials
An enzyme-free glucose electrochemical sensor based on carbon dots(CDs)and metal-organic framework(MOF)composites was constructed.Three kinds of carbon dots with different doping elements(C-CDs,B-CDs and N-CDs)were prepared by hydrothermal method,and then combined with ZIF-67 respectively to obtain three kinds of CDs@ZIF-67 composite materials,which were modified on glassy carbon electrode(GCE)to construct highly sensitive enzyme-free glucose electrochemical sensor.The combination of CDs and ZIF-67 could effectively improve the poor electrical conductivity of MOFs,and then improve their catalytic activity toward glucose.When nitrogen element was doped in CDs,nitrogen element induced more defects on CDs surface and speeded up the electron transfer rate.Therefore,N-CDs@ZIF-67 exhibited the best electrocatalytic performance for glucose.N-CDs@ZIF-67/GCE was used to construct an electrochemical sensor,and the response current showed a good linear relationship with the concentration of glucose in the range of 0.1-1000 μmol/L and 1000-7000 μmol/L,respectively,with a detection limit of 31.8 nmol/L(S/N=3).The sensor was successfully applied to detection of glucose in real human serum samples.The recoveries were 101.5%-109.0%,and the relative standard deviations were less than 3.1%.The fabricated sensor exhibited potential practicability for detection of glusose in real samples.
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