基于碳点与金属有机框架复合材料的葡萄糖直接电化学传感平台
Direct Electrochemical Glucose Sensing Platform Based on Carbon Dots and Metal-Organic Framework Composite Materials
颜文菊 1张子豪 1庞元昊 1周雪英 1王钰 1袁亚利2
作者信息
- 1. 桂林理工大学 化学与生物工程学院,桂林 541004
- 2. 桂林理工大学 化学与生物工程学院,桂林 541004;桂林理工大学 食品安全与检测广西重点实验室,桂林 541004
- 折叠
摘要
构建了一种基于碳点(CDs)与金属有机框架(MOF)复合材料的无酶葡萄糖电化学传感器.采用水热法分别制备了不掺杂、掺杂硼和掺杂氮的3种碳点C-CDs、B-CDs和N-CDs,进一步分别与ZIF-67进行复合,制得3种CDs@ZIF-67复合材料,将其修饰在玻碳电极(GCE)上,构建了高灵敏无酶葡萄糖电化学传感器.CDs与ZIF-67的复合能够有效改善MOFs导电性较差的问题,进而改善其催化活性.CDs掺杂N元素后,N元素诱导CDs表面产生更多的缺陷,加快了电子转移速率,因此N-CDs@ZIF-67的电催化性能最佳.基于N-CDs@ZIF-67修饰GCE构建的传感器的响应电流与葡萄糖浓度在0.1～1000 μmol/L和1000～7000 μmol/L两段范围内分别呈良好的线性关系,检出限(S/N=3)为31.8 nmol/L.将此传感器用于实际人血清样本中葡萄糖的检测,加标回收率为101.5%～109.0%,相对标准偏差(RSD)小于3.1%,显示出良好的实用性.
Abstract
An enzyme-free glucose electrochemical sensor based on carbon dots(CDs)and metal-organic framework(MOF)composites was constructed.Three kinds of carbon dots with different doping elements(C-CDs,B-CDs and N-CDs)were prepared by hydrothermal method,and then combined with ZIF-67 respectively to obtain three kinds of CDs@ZIF-67 composite materials,which were modified on glassy carbon electrode(GCE)to construct highly sensitive enzyme-free glucose electrochemical sensor.The combination of CDs and ZIF-67 could effectively improve the poor electrical conductivity of MOFs,and then improve their catalytic activity toward glucose.When nitrogen element was doped in CDs,nitrogen element induced more defects on CDs surface and speeded up the electron transfer rate.Therefore,N-CDs@ZIF-67 exhibited the best electrocatalytic performance for glucose.N-CDs@ZIF-67/GCE was used to construct an electrochemical sensor,and the response current showed a good linear relationship with the concentration of glucose in the range of 0.1-1000 μmol/L and 1000-7000 μmol/L,respectively,with a detection limit of 31.8 nmol/L(S/N=3).The sensor was successfully applied to detection of glucose in real human serum samples.The recoveries were 101.5%-109.0%,and the relative standard deviations were less than 3.1%.The fabricated sensor exhibited potential practicability for detection of glusose in real samples.
关键词
金属有机框架/碳点/葡萄糖/电化学传感器Key words
Metal-organic framework/Carbon dots/Glucose/Electrochemical sensor引用本文复制引用
出版年
2024
国家科技期刊平台
NSTL
万方数据