基于环状构象两性离子聚合物的抗粘附/光热杀菌表面性能分析
Anti-adhesion/Photothermal Bactericidal Surface Based on a Looped Polyzwitterion
夏效禹 1张光宇 2苏朝晖1
作者信息
- 1. 中国科学院长春应用化学研究所,高分子物理与化学国家重点实验室,长春 130022;中国科学技术大学应用化学与工程学院,合肥 230026
- 2. 中国科学院长春应用化学研究所,高分子物理与化学国家重点实验室,长春 130022
- 折叠
摘要
耐药细菌附着在医疗器械表面易引起感染,对公众健康造成严重威胁,因此,研发长效抗粘附与杀菌表面具有重要的意义.本研究在玻璃基底表面顺序沉积聚多巴胺(PDA)、银纳米粒子(AgNPs)和PDA,然后在PDA表面接枝环状构象的聚磺酸甜菜碱(PSBMA),构建了具有抗粘附与光热杀菌作用的双重抗菌涂层PAP-PSBMA-loop.该涂层具有两性离子聚合物表面优良的抗污能力和PDA与AgNPs良好的光热转化能力,在近红外光辐照下显示出优异的抗细菌粘附与杀菌性能,与细菌共孵育7d后,表面的细菌覆盖率仅为1.7%,有效地阻止了生物被膜的形成,在光照下可杀灭99%以上的表面细菌.
Abstract
Infections caused by drug-resistant bacteria attaching to medical devices pose significant challenges to public health,and as such development of anti-adhesion and bactericidal surfaces with long-term performance is of practical importance.In this study,polydopamine(PDA),silver nanoparticles(AgNPs)and PDA were sequentially deposited on the glass substrate,and then polysulfobetaine methacrylate(PSBMA),a zwitterionic polymer,with a loop conformation was grafted onto the PDA surface to construct PAP-PSBMA-loop,a dual-functional antibacterial coating combining bacterial adhesion-resistance and photothermal sterilization properties.Due to the robust antifouling ability of the zwitterionic polymer and the excellent photothermal conversion ability of PDA and AgNPs,PAP-PSBMA-loop coating demonstrated excellent resistance to bacterial adhesion and sterilization performance under near-infrared(NIR)irradiation.After 7 days of incubation with bacteria,the coating surface exhibited a low bacterial coverage of 1.7%,and was able to suppress biofilm formation effectively and kill>99%of the bacteria that managed to adhere upon exposure to NIR irradiation.
关键词
光热杀菌/抗菌表面/环状构象/抗污涂层/银纳米粒子Key words
Photothermal sterilization/Antibacterial surfaces/Loop conformation/Antifouling coatings/Silver nanoparticles引用本文复制引用
出版年
2024
国家科技期刊平台
NSTL
万方数据