提高离子迁移谱性能的双效应Tyndall-Powell门控方法研究
Enhancing Performance of Ion Mobility Spectrometry Based on a Dual Effect Tyndall-Powell Gate Controlling Method
张根伟 1杨其穆 2徐一仟 2杨杰 1潘慢慢 2蒋丹丹 2陈创3
作者信息
- 1. 国民核生化灾害防护国家重点实验室,北京 102205
- 2. 中国科学院大连化学物理研究所,仪器分析化学研究室,大连 116023
- 3. 国民核生化灾害防护国家重点实验室,北京 102205;中国科学院大连化学物理研究所,仪器分析化学研究室,大连 116023
- 折叠
摘要
离子迁移谱(Ion mobility spectrometry,IMS)检测速度快、灵敏度高、可便携,在化学毒剂、爆炸物、毒品和环境污染物等现场检测中发挥了重要作用.离子门作为IMS的关键部件,其向迁移区内注入离子团的离子数和时间宽度直接影响检测灵敏度和分辨能力.本研究采用Tyndall-Powell离子门(TPG)双平行栅结构可有效隔离电离区、离子门区和迁移区电场并独立调控的优势,发展了一种可以使迁移率歧视消除与离子团时域压缩同步增强的双效应TPG门控方法,提升了IMS的性能.搭建了TPG-IMS平台,考察了双效应TPG门控方法的离子门开门时间、离子门穿透电压和离子注入电压等参数对IMS信号强度和分辨能力的影响.结果表明,采用双效应TPG门控方法检测磷酸二乙酯(Diethyl phosphonate,DEP)和甲基磷酸二乙酯(Diethyl methylphosphonate,DEMP)混合样品,可以使迁移率(K0)较小的(DEP)2H+和(DEP·DEMP)H+的离子峰强度分别提升 18 和 45 倍,并保持分辨能力为～90,实现综合门控效能的提升;DEP的检出限从4 ppb(10-9)降至235 ppt(10-12),DEMP的检出限从5 ppb降至156 ppt.此门控方法仅调控TPG紧邻迁移区栅极的电势,无需改变迁移管结构,便于在现有商品化仪器上推广应用.
Abstract
Ion mobility spectroscopy(IMS)has many advantages such as fast detection speed,high sensitivity,and portability,and thus plays an important role in on-site detection of chemical agents,explosives,drugs,environmental pollutants,and other pollutants.As a key component of IMS,the ion number density and temporal width of the injected ion packets directly determine the IMS detection sensitivity and resolution.In yhis study,the dual-parallel-grid structure of Tyndall-Powell gate(TPG),which could effectively isolate the electric fields within the ionization region,gate region,and drift region,was utilized to develop a dual effect TPG gating method for simultaneously enhancing the mobility discrimination reduction and ion packet temporal width compression,thereby improving the IMS performance.A TPG-IMS platform was thus built up and the effects of parameters such as gate opening pulsed width,gate penetration voltage,and ion injection voltage on the sensitivity and resolving power of IMS were systematically investigated using the dual-effect TPG gating method.The results demonstrated that,when detecting diethyl phosphate(DEP)and diethyl methylphosphate(DEMP)mixture using the dual effect TPG gating method,the peak currents of(DEP)2H+and(DEP·DEMP)H+ions with low K0 values were increased by 18 and 45 times respectively,while maintaining a high resolution of about 90.The limits of detection for DEP and DEMP were decreased from 4 ppb(10-9)to 235 ppt(10-12)and from 5 ppb to 156 ppt,respectively.This gating method only regulated the potential of the TPG grid adjacent to the drift region,without changing the structure of the ion mobility tube,making it convenient to apply on existing commercial instruments.
关键词
离子迁移谱/双平行栅离子门/迁移率歧视/离子团时域压缩/综合门控效能Key words
Ion mobility spectrometry/Parallel dual-grid ion gate/Mobility discrimination/Temporal compression/Comprehensive gating performance引用本文复制引用
基金项目
国家自然科学基金(21974141)
国家自然科学基金(22027804)
辽宁省自然科学基金(2022-MS-016)
辽宁省自然科学基金(2022-MS-019)
国民核生化灾害防护国家重点实验室科研项目(SKLNBC2021-16)
大连化物所创新研究基金(DICPI202141)
大连化物所创新研究基金(DICPI202422)
出版年
2024
国家科技期刊平台
NSTL
万方数据