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无机声敏剂在肿瘤治疗和诊断中的研究进展

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声动力治疗是一种以超声刺激声敏剂产生活性氧进而诱导癌细胞死亡的癌症治疗新方法.相较于有机声敏剂,无机声敏剂在稳定性、毒性、水溶性、肿瘤靶向性和功能调控等方面更具优势,在肿瘤的治疗和诊断方面显示出广阔的应用前景.得益于无机声敏剂优异的性质,目前研究者开发出众多基于无机纳米材料的声敏剂,主要包括钛基声敏剂、其它金属基声敏剂和非金属基声敏剂,并探索了其在肿瘤诊疗方面的应用.本文介绍了无机声敏剂的作用机理,即声动力治疗机理,概述了不同体系的无机声敏剂在肿瘤治疗和诊断中的研究进展,总结了提高声动力治疗效果的方法,并对目前无机声敏剂存在的问题和未来的发展前景进行了总结和展望.
Recent Advances in Inorganic Sonosensitizers for Tumor Diagnosis and Treatment
Sonodynamic therapy(SDT)is an emerging approach of cancer treatment that stimulates sonosensitizers by ultrasound to produce reactive oxygen species(ROS)and induce cancer cell death.Compared with organic sonosensitizers,inorganic sonosensitizers have many advantages in stability,toxicity,water solubility,tumor targeting and functional regulation,showing extensive potentials in diagnosis and treatment of tumors.Thanks to the excellent properties,numerous sonosensitizers based on inorganic nanomaterials have been reported,mainly including titanium-based sonosensitizers,other metal-based sonosensitizers and non-metal-based sonosensitizers,and their prospects in diagnosis and treatment of tumor have been discussed.This review introduced the mechanism of SDT,overviewed the research progress of different systems of inorganic sonosensitizers in treatment and diagnosis of tumor,and summarized the methods to improve the therapeutic effect of SDT.Finally,the existing problems and development perspective of inorganic sonosensitizers were discussed and prospected.

Inorganic sonosensitizersSonodynamic therapyImaging diagnosisReview

刘新静、张若浩、付欣玉、冯婧、张洪杰

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中国科学院长春应用化学研究所,稀土资源利用国家重点实验室,长春 130022

中国科学技术大学应用化学与工程学院,合肥 230026

清华大学化学系,北京 100084

无机声敏剂 声动力治疗 成像诊断 评述

2024

分析化学
中国化学会 中国科学院长春应用化学研究所

分析化学

CSTPCD北大核心
影响因子:1.423
ISSN:0253-3820
年,卷(期):2024.52(12)
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