Identification of Benzene Series Metabolites in Mussels by UPLC-Q-TOF-MS
Due to the toxic effect of benzene series on marine ecosystem and species differences in the metabolism of organisms,in order to explore the potential metabolic detoxification pathway and metabolites of typical benzene series in mussels,the metabolites produced by benzene,toluene and xylene were identificatied by UPLC-Q-TOF-MS with Waters UNIFI data information system.The results showed that benzene,toluene and xylene produced 6 benzene metabolites,9 toluene metabolism and 8 xylene metabolites in mussels,respectively,with metabolic pathways of hydration,reduction,desturation,oxidation,sulfation,dihydrodiol formation,methylation,glucuronidation,etc.Among them,the xylene metabolite X-7 is the isomorphism of DPMA,and the metabolites of other benzene series are the first report.The metabolic detoxification pathway and metabolites of benzene series obtained in mussels,and the developed UPLC-Q-TOF-MS analysis method,have enriched the Marine ecological environment monitoring system and provided theoretical basis and data reference for the safety assessment of offshore Marine ecological environment in China.
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维普
