Carbon Fiber Ultramicroelectrode Modified by Reduced Graphene Oxide-MXene Three-dimensional Aerogel for Nitric Oxide Detection
As an important secondary messenger in human body,nitric oxide(NO)plays a key role in a variety of physiological processes.It is necessary to detect NO in vivo with high sensitivity and selectivity.Based on the rapid,accurate and highly sensitive electrochemical methods,this study proposed a carbon fiber ultramicroelectrode modified by reduced graphene oxide(rGO)-MXene composite for NO detection.Carbon fiber ultramicroelectrode possessed the advantages of small volume,good biocompatibility and high sensitivity,which would decrease the stimulation and damage to organism.The sensitivity and selectivity of the electrode were improved by using the large specific surface area,high conductivity and abundant porous structure of the rGO-MXene composite,the high catalytic performance of gold nanomaterials for NO,the high electrical conductivity and molecular filtration performance of polyaniline and polyphthalamine.The linear detection range of NO was 0.11 μmol/L-235.67 μmol/L(R2=0.998),the detection limit was 16.8 nmol/L(S/N=3),and the sensitivity was 0.23 nA/(μmol/L).The electrode did not respond to common interferences in the body such as ascorbic acid and dopamine,and had strong anti-interference ability.
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