Determination of the Migration of Endocrine Disruptors from Children's Face Cream by Hydroxylated Multi-walled Carbon Nanotubes Solid Phase Extraction Combined with Liquid Chromatography-Tandem Mass Spectrometry
A method for determination of the migration of 13 endocrine disruptors in children's face cream was developed.The sample was extracted with ammonia and acetonitrile(1∶9,V/V),purified by hydroxylated multi-walled carbon nanotubes solid phase extraction,then detected by liquid chromatography-tandem mass spectrometry in negative electrospray ionization mode,and quantified by matrix external standard method.Under the optimal experimental conditions,the linear correlation coefficients of 13 endocrine disruptors were 0.9915-0.9996,the detection limits were 0.3-1.5 μg/kg,and the limits of quantification were 1.0-5.0 μg/kg.The recoveries were 81.5％-109.4％with the relative standard deviations of 1.9％-9.2％at three spiked levels.The method is convenient,selective and sensitive,and can be used for the determination of endocrine disruptors in children's face cream.
Hydroxylated multi-walled carbon nanotubesLiquid chromatography-tandem mass spectrometryEndocrine disruptorsMigrationChildren's face cream
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