Study on Host-guest Interaction of Methamphetamine with Cucurbit[7]uril by Fluorescent Probe
Methamphetamine(MA)is a powerful stimulant drug of abuse with potent addictive and neurotoxic properties.The competitive reaction of MA with palmatine(PAL)fluorescent probe for the occupancy of the cucurbit[7]uril(CB[7])cavity was studied using absorption,spectrofluorimetry,molecular modeling theoretical calculations,and 1H NMR.The PAL-CB[7]complex exhibited high fluorescence in aqueous solution,which was quenched in the presence of MA.The fluorescence quenching values(ΔF)showed good linear relationship with MA concentrations from 0.05 to 1 μg/mL with a detection limit of 6 ng/mL.Based on the significant quenching of the complex fluorescence intensity,a simple spectrofluorimetric method with high sensitivity and selectivity was developed to determine the content of MA in human urine.
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