The Bengal Rose Resonance Light Scattering Spectroscopy Method for Determination of Chlorpheniramine Maleate Content
The study aimed to establish a rapid detection method for determination of chlorpheniramine maleate content using resonance light scattering spectroscopy.The experimental results demonstrated that in pH 3.0 Clark-Lubs buffer solution,Bengal rose could react with chlorpheniramine maleate,causing variations in the resonance light scattering spectrum.The intensity difference of the resonance light scattering peak increased with the concentration of chlorpheniramine maleate.At a wavelength of 309 nm,the intensity difference of the resonance light scattering spectrum reached its maximum.The intensity difference of the resonance light scattering(ΔIRLS)exhibited a linear relationship with chlorpheniramine maleate concentration in the range of 0.05-0.40 mg/L,with a correlation coefficient of 0.9996.The detection limit of the method was 0.0418 mg/L.
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