In realtime traj ectory estimation based on Unscented Kalman Filter (UKF),the influence of unstable ex-ternal environment and existence of outliers made filtering results inaccurate or even divergent. Therefore,it was necessary to adj ust and determine values of filter parameters properly to overcome the problem before a missile launch. A robust design of filter parameters based on theoretical traj ectory as prior information was proposed to pre-dict the optimal value of parameters. Starting from the perspective of filter framework,this paper selected relevant parameters,adopted the idea of robust design,constructed a ballistic measurement model through simulating trajec-tory feature points based on theoretical traj ectory in outer design;and carried out orthogonal experimental design by reversing measurement data from constructed model,then j udged the significance of the parameters and determined its optimal value,so as to give guidance to parameter setting of realtime traj ectory estimation. Examples show that this method is of high validity,and can improve the robustness and convergence performance of the filter.