Preparation and performance of electrospun sodium alginate composite nanofiber membranes
Objective This study aimed to harness the biocompatibility,biodegradability,and anti-adhesion properties of sodium alginate(SA)for potential use in wound dressings.Utilizing environmentally friendly deionized water as a solvent,a composite nanofiber membrane of SA,polyethylene oxide(PEO),and polyvinylpyrrolidone(PVP)was fabricated through a modified small linear trough electrospinning device.The research focused on optimizing the solution's conductivity,fiber morphology,and diameter distribution of the spinning solution to enhance the spinnability of the SA solution and improve the functional properties of the final membrane.Method The optimal solution mixture was determined through the analysis of solution conductivity,fiber morphology,and diameter distribution.The prepared nanofiber membranes were crosslinked by 3.0％anhydrous ethanol solution of calcium chloride(CaCl2)for varying durations(0,2,4,8,12,24 h).After post-treatment,the samples were systematically analyzed for microscopic morphology,chemical structure,swelling behavior,and structural stability to evaluate the effects of cross-linking on membrane properties.Results With a mass ratio of 1:4 between SA and PEO,4％total solute mass fraction,and PVP constituting 10％of the total solute mass,the SA/PEO/PVP composite nanofiber membranes exhibited uniform morphology with fibers averaging 240 nm in diameter and forming a three-dimensional interwoven network.This network structure was crucial for achieving significant mechanical strength and durability.Cross-linking for 24 h resulted in enhanced water resistance and structural stability,with a swelling ratio of 1 050.80％and a mass loss rate of 40.63％,indicating superior physical properties.Conclusion The study successfully developed SA/PEO/PVP composite nanofiber membranes with excellent morphology and enhanced performance after CaCl2 cross-linking.The introduction of PEO and PVP not only improved the spinnability of SA but also contributed to the compatibility within the composite,underscoring the potential of these membranes as substrates for wound healing applications.This research emphasizes the innovation of using deionized water as a solvent in a non-toxic spinning process,addressing environmental concerns related to organic solvents.This provides strong evidence for promoting wound healing in accordance with the principles of moist wound healing and offers new insights and directions for the development of advanced wound care solutions.
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