The P Oilfield is the Bohai Sea's largest continental multilayer sandstone reservoir.After more than ten years of waterflooding development,the oilfield has entered the medium-high water-cut stage.Due to the high and significant differences in the reservoir siltstone and mud content,the three major development contradictions of the intra-,inter-,and planar layers are prominent.The conventional digital model is more challenging to fit the rising water-cut law of a single well,which greatly influences the numerical simulation fitting and development index prediction of the reservoir.Based on the analysis of oilfield reservoir microstructure,the relationship formula between the ratio of water drive ratio and permeability change of different types of reservoirs is established by the experimental study of long-term water drive reservoir micro-pore structure change,the statistical analysis of reservoir water-flooded physical property change rule in field adjustment well,and the interpretation of porosity and permeability method by logging in the P Oilfield,as well as water drive oil experiment and water-flooded physical property change rule.The PetrelRE platform and Intersect simulator are used to realize the local reservoir permeability-increasing or decreasing process during waterflooding development,which significantly improves the fitting of the water-cut rise rule in a single well.