Effect of hyperlipidemia on left ventricular function in patients with type 2 diabetes mellitus by left ventricular automatic strain analysis
Objective To evaluate the left ventricular function in patients with type 2 diabetes mellitus(T2DM)by left ventricular automatic strain analysis,and to verify whether hyperlipidemia aggravates left ventricular dysfunction in patients with T2DM,and to explore the risk factors related to left ventricular strain.Methods Eighty-six patients with T2DM were divided into DM1 group(without hyperlipidemia,n=43)and DM2 group(with hyperlipidemia,n=43).Forty-three healthy volunteers were selected as the control group.All participants underwent conventional echocardiography and left ventricular automatic strain analysis to obtain conventional ultrasound measurements and left ventricular apical four-chamber global longitudinal strain(GLSA4c),left ventricular apical three-chamber global longitudinal strain(GLSA3C),left ventricular apical two-chamber global longitudinal strain(GLSA2C),left ventricular mean global longitudinal strain(GLSavg),left atrial storage strain(LASr),left atrial channel strain(LAScd),left atrial systolic strain(LASct).The differences of observation indexes between groups were compared,and multiple linear regression analysis was used to determine the independent risk factors affecting left ventricular strain.Results Compared with the control group,LVGLSA4C,LVGLSA3C,LVGLSA2C,LVGLSavg,LASr and LAScd were significantly decreased in DM1 group(P<0.05).LVGLSA4C,LVGLSA3C,LVGLSA2C,LVGLSavg,LASr and LAScd in DM2 group were significantly lower than those in the other two groups(P<0.05).It was estimated that total cholesterol was negatively correlated with the absolute values of left ventricular LVGLSA4C,LVGLSA3C,LVGLSA2C,LVGLSavg,LASr and LAScd(P<0.001),triglyceride was negatively correlated with the absolute values of left ventricular LVGLSA4C,LVGLSA3C,LVGLSA2C,LVGLSavg,LASr and LAScd(P<0.001).The results of multiple linear regression analysis showed that the absolute values of LVGLSA4C,LVGLSA3C,LVGLSA2C,LVGLSavg,LASr and LAScd were independently correlated to TG(P<0.05).Conclusion The left ventricular strain in patients with T2DM is significantly impaired,and hyperlipidemia can aggravate the deterioration of left ventricular strain in diabetic patients.TG may be an independent risk factor for predicting left ventricular strain reduction.
type 2 diabeteshyperlipidemiaautomatic left heart strain quantitative analysis technologyechocardiography
万方数据
维普
