Relationship between and FNA-Tg and the size of metastatic lymph nodes from papillary thyroid carcinoma
Objective To analyze the relationship between and the value of FNA-Tg and the size of metastatic lymph nodes from papillary thyroid carcinoma(PTC).Methods The clinical data of 96 patients with suspected cervical lymph node metastasis or recurrence of thyroid papillary carcinoma in Ruijin Hospital affiliated to Medical College of Shanghai Jiaotong University from April 2018 to January 2019 were collected.A total of 136 suspicious cervical lymph nodes from 96 PTC patients were prospectively included,and the lymph nodes were divided into benign and malignant according to the results of aspiration cytology or paraffin pathology.The long and short axes of each lymph node on the largest section were measured by ultrasound,each suspected lymph node was aspirated with a 22-gauge needle,then FNA-Tg was measured.ECL analyzer(Cobas E602,Roche,Switzerland)and ELEXSYS TG II kit were used to determine the Tg value of FNA-Tg samples.Serological examination of thyroid function was performed in all patients within 2 weeks before FNA.The relationship between metastatic lymph node size and FNA-Tg in PTC patients was analyzed.Results Among the 136 lymph nodes,89(65.44%)were diagnosed as metastatic lymph nodes and 47(34.56%)were benign.The level of FNA-Tg in metastatic lymph nodes was significantly higher than that in non-metastatic lymph nodes(median 631.550 ng/mL vs 0.056 ng/mL).The cut-off value of FNA-Tg and FNA-Tg/sTg in the diagnosis of metastatic lymph nodes was 2.71 ng/mL and 6.50 ng/mL separately.There was no significant correlation between the size of lymph nodes and FNA-Tg(P>0.05).Conclusion The FNA-Tg level of metastatic lymph nodes in PTC patients is significantly higher than that of non-metastatic lymph nodes.The size of lymph nodes alone can not predict the level of FNA-Tg.
万方数据
维普
