A quantitative study of magnetic resonance ESWAN sequence on the establishment of a hierarchy of cerebral microbleeds lesions
Objective To enhance the grading criteria for cerebral microbleeds(CMBs)imaging diagnosis by applying the phase value(PV)of magnetic resonance enhanced gradient echo GRE T2-star weighted angiography(ESWAN)sequences.Methods A retrospective analysis was conducted on 100 patients with cerebral small vessel disease(CSVD)presenting CMBs and 29 healthy volunteers without any abnormal brain imaging findings or underlying diseases,who underwent ESWAN sequence scans at Xiangya Hospital of Central South University from May 2021 to May 2022.The CSVD group was divided into CMBs group,lacunar infarction(LI)group(CMBs with LI only),white matter lesions(WML)group(CMBs with WML only),and LI+WML group based on the lesion diagnosis results.LI confined to two brain regions and with fewer than three lesions was defined as scattered LI,otherwise as multiple LI;Fazekas grade I was defined as mild WML,otherwise as severe WML.Hospital post-processing software was used to outline and measure the PV of each CMBs lesion in the CSVD group and the red nucleus and substantia nigra in the healthy group,analyzing the differences in PV values between CMBs lesions and the healthy red nucleus and substantia nigra,and the relationship between LI,WML lesions occurrence and PV values of CMBs.Results Statistical significance was found in the differences between the average PV values of CMBs lesions in various brain regions of the CSVD group and the red nucleus and substantia nigra of the healthy group(F=65.599,P<0.001);Differences in average PV values of CMBs were statistically significant across different degrees of WML lesions and numbers of LI lesions(P<0.05),showing a negative correlation(P=0.027,0.047).Based on the degree of impact,preliminary definitions were established:Grade I CMBs as PV values>-0.74,grade II CMBs as PV values between-0.81 and-0.74,grade III CMBs as PV values between-0.84 and-0.81,grade IV CMBs as PV values between-0.89 and-0.84,and grade V CMBs as PV values<-0.89.Conclusion CMBs lesions and the severity of LI and WML lesions mutually influence each other;PV values from magnetic resonance ESWAN sequences can quantitatively reflect the severity of CMBs lesions.Based on this,a grading system for CMBs lesions is established,helping to replace the currently more subjective manual counting assessment method.This aids in the precise detection of early CMBs lesions and rapid diagnosis of CSVD at its initial stages.
cerebral microbleedsenhanced gradient echo GRE T2-star weighted angiographymagnetic resonancequantitative diagnosis
万方数据
维普
