Influence of exposure to a closed and isolated occupational environment on seafarers brain function by resting-state fMRI
Objective To investigate the effects of marine closed isolation environment and exposure years on seafarers'brain function,and to provide evidence for preventing occupational environmental exposure to seafarers'brain function injury.Methods In August 2023,30 male professional seafarers who have been engaged in marine operations for a long time were recruited as seafarer group,aged 19～29 years old and with 1～11 years of working experience.Resting-state functional brain MRI was performed on seafarers using the Magneton Skyra 3.0 T MRI scanner in Sanya People's Hospital.A total of 30 subjects with no experience of working at sea were matched as control group,aged 18～28 years old.The Magneton Skyra 3.0 T resting-state magnetic resonance data for the control group were downloaded from the OpenNeuro public database.The resting state ALFF,fALFF and ReHo indexes of the two groups were calculated.The two-sample t-test was used to compare the differences of ALFF,fALFF and ReHo between the two groups,and the correlation between ALFF,fALFF and ReHo values and the working years and years of at sea was further analyzed by partial correlation analysis.Results Compared with control group,the ALFF values of the right postcentral gyrus and right cerebellar foot area 1 were higher in the seafarer group,and the ALFF values of the left olfactory cortex were lower in the seafarer;The fALFF values of left median cingulate and paracingulate gyrus and right superior temporal gyrus were higher in the seafarer group compared with the control group,and the fALFF values of right middle occipital gyrus,left inferior parietal angular gyrus,left precentral gyrus and right precentral gyrus were lower in the seafarer group;The ReHo values of the right parahippocampal gyrus were higher in the seafarer group,and the ReHo values of the right inferior temporal gyrus,the right orbital middle frontal gyrus,the left inferior parietal angular gyrus,the left angular gyrus,the right middle temporal gyrus and the left middle temporal gyrus were lower in the seafarer group.All the above differences were statistically significant(P<0.05),corrected by GRF,with voxel levels P<0.001 and cluster levels P<0.05.In the seafarer group,there was a weak positive correlation between the ALFF values of the right posterior central gyrus and the working years(r=0.369,P=0.049),and the values of fALFF of the right middle occipital gyrus was weak negative correlated with the working years(r=-0.370,P=0.048).Conclusion Long-term exposure to occupational closed isolation environment had an effect on the brain function activities of seafarers in multiple brain regions,and there was a weak positive correlation between the ALFF values of the right postcentral gyrus and the working years,and the fALFF values of the right middle occipital gyrus was weak negative correlated with the working years.
closed and isolated environmentresting-state functional magnetic resonancebrain functionseafarers
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