Application and prognostic value of indocyanine green combined with highly sensitive fluorescence image-guided surgery system in breast-conserving surgery of breast cancer
Objective To explore the application value of indocyanine green(ICG)combined with highly sensitive fluorescence image-guided surgery system in breast-conserving surgery for breast cancer.Methods A total of 91 patients with axillary lymph node-negative primary breast cancer who came to Affiliated Jiangsu Shengze Hospital of Nanjing Medical University for treatment from May 2017 to October 2020 were selected.According to the different methods of ICG intraoperative localization,the patients were divided into control group(preoperative metal guide wire localization guidance,n=33)and observation group(ICG localization guidance,n=58).The operation time,whether the surgical margin was clean,the width of the resection margin,and the tumor size(average volume)of the two groups were recorded,postoperative serum tumor index CA15-3 and carcinoembryonic antigen,and the prognosis survival without local recurrence,disease-free survival rate and overall survival rate were observed.Results Compared with the control group,there were no significant differences between observation groups in positive margins,tumor resection volume,operation time,serum CA15-3 and carcinoembryonic antigen levels after operation,disease-free survival rate and overall survival rate(P>0.05),while the number of tumor margins≤2 mm and survival rate without local recurrence increased,and the difference between groups was statistically significant(P<0.05).Conclusion ICG combined with highly sensitive fluorescence image-guided surgery system can effectively reduce the width of breast cancer surgical margins,and the patients'prognosis is good.
indocyanine greenhighly sensitive fluorescence image-guided surgery systembreast cancerbreast-conserving surgery
万方数据
维普
