Clinical and CT imaging features of Mycobacterium kansasii pulmonary disease
Objective To explore the clinical and CT features of patients with Mycobacterium kansasii pulmonary disease,so as to improve the understanding,diagnosis and treatment of this disease.Methods A retrospective analysis was conducted on the clinical and CT imaging data of 66 patients with Mycobacterium kansasii pulmonary disease(kansasii group)admitted to Guangzhou Chest Hospital from January 2021 to December 2022.An additional 80 patients with active pulmonary tuberculosis(tuberculosis group)were selected and compared in terms of age,gender,and CT features between the two groups.Results The main symptoms of Mycobacterium kansasii pulmonary disease are cough,sputum,hemoptysis,chest tightness,fever,and chest pain.The resistance rates of Mycobacterium kansasii to commonly used anti-mycobacterium drugs were 1.5%for rifampicin,3.0%for Bedaquiline,4.5%for ethambutol and clofazimine,9.1%for protionamide,12.1%for levofloxacin,15.2%for moxifloxacin,25.8%for linezolid,and 95.5%for isoniazid,amikacin,and capreomycin.The positive rate of γ-interferon release assays(IGRAs)in patients with Mycobacterium kansasii pulmonary disease was 32.4%(12/37).The main CT findings include lobular central nodules,cavities,bronchiectasis,ground-glass opacities,fibrous cord opacities,consolidation and lung volume decreased.The proportion of lesions with a distribution range of less than 3 lobes in the kansasii group was higher than that in the tuberculosis group,while the proportion of lung volume decreased,consolidation,and pleurisy was lower than that in the tuberculosis group(P<0.05).The proportion of solitary cavities,cavities distributed in the upper right lung,and the largest cavity located outside field of the lung in the kansasii group was higher than that in the tuberculosis group,while the wall thickness of the largest cavity was lower than that in the tuberculosis group(P<0.05).Conclusion The CT manifestations of Mycobacterium kansasii pulmonary disease have certain characteristics and are of great value in distinguishing it from active pulmonary tuberculosis.
万方数据
维普
