首页|慢阻肺脑结构与功能的MRI研究进展

慢阻肺脑结构与功能的MRI研究进展

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慢性阻塞性肺疾病不仅能够累及肺部也可造成全身的不良反应，而肺外效应又可加重其严重程度，其中脑损害逐渐受到研究者的重视。近年来，神经医学影像技术取得了长足进步，特别是基于体素的形态测量学技术、弥散张量成像技术、磁共振波谱成像技术以及功能磁共振成像技术等，不仅能够无创的对机体的形态及结构进行观察检测，还能够提供其功能代谢等微观方面的变化信息。本文现从磁共振多参数成像技术角度对慢性阻塞性肺疾病患者脑结构及功能改变的特点、可能机制及研究现状等方面进行综述，以期磁共振成像技术更广泛成熟的应用于神经科学领域以及中枢神经系统疾病研究，从而为深入学习和研究慢性阻塞性肺疾病的病理生理学机制、协助临床诊疗和疾病预后转归提供全新的方法和可供参考的重要信息。
Advances in MRI research on the brain structure and function in chronic obstructive pulmonary disease
Chronic obstructive pulmonary disease can not only involve the lungs but also cause systemic adverse reactions,and extrapulmonary effects can aggravate its severity,in which brain damage is gradually gaining attention from researchers.In recent years,neurological imaging technology has made great progress,especially based on voxel morphometry,diffusion tensor imaging,magnetic resonance spectroscopy and functional magnetic resonance imaging,which can not only non-invasively observe and detect the morphology and structure of the body,but also provide microcosmic information such as functional metabolism.This article reviews the characteristics,possible mechanism and research status of brain structural and functional changes in patients with chronic obstructive pulmonary disease from the perspective of MRI multi-parameter imaging,with a view to the more extensive and mature application of MRI in the field of neuroscience and the study of central nervous system diseases.Thus,it provides a new method and important information for further study and study of the pathophysiological mechanism of chronic obstructive pulmonary disease,clinical diagnosis and treatment and prognosis of the disease.

chronic obstructive pulmonary diseasemagnetic resonance imaging technologybrain damagebrain structure and functionresearch progress

李昆、李宁、杨建雅、张静懿、张旭、李素云

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河南中医药大学第一临床医学院,河南 郑州 450046

河南中医药大学第一附属医院呼吸科,河南 郑州 450000

慢性阻塞性肺疾病 磁共振成像技术 脑损伤 脑结构与功能 研究进展

国家自然科学基金河南省中医药科学研究专项河南省中医药科学研究专项河南省科技厅-河南省财政厅科技研发计划联合基金(2022)

820744132022JDZX0132019JDZX2035222301420081

2024

10.12122/j.issn.1674-4500.2024.03.18

分子影像学杂志
南方医科大学

分子影像学杂志

CSTPCD
ISSN：1674-4500
年,卷(期)：2024.47(3)
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