Changes and clinical significance of levels of serum TSP1,TSP2,bFGF,VEGF and S-100β in patients with chronic subdural hematoma treated by drilling and drainage
Objective To explore the changes and clinical significance of levels of serum platelet-reactive protein 1(TSP1),platelet-reactive protein 2(TSP2),basic fibroblast growth factor(bFGF),vascular endothelial growth factor(VEGF)and central nervous system specific protein(S-100β)in patients with chronic subdural hematoma treated by drilling and drainage.Methods A total of 142 patients with chronic subdural hematoma admitted to Jiangsu Province Hospital of Traditional Chinese Medicine from January 2019 to June 2023 were selected as the case group,and all of them underwent drilling and drainage.Another 146 healthy people in the same period were selected as the healthy control group.The levels of serum TSP1,TSP2,bFGF,VEGF,S-100β were compared between the case group and the healthy control group,with different brain injuries,before and after operation and with different recurrence,and the serum TSP1,TSP2,bFGF,VEGF,S-100β were analyzed by Pearson correlation.Results Compared with the healthy control group,the levels of serum TSP1,TSP2,bFGF,VEGF,S-100β in the case group were relatively higher.Compared with the mild brain injury group,the levels of serum TSP1,TSP2,bFGF,VEGF and S-100β in the moderate brain injury group and severe brain injury group were relatively higher,and the severe brain injury group was higher than the moderate brain injury group.Compared with before operation,the levels of serum TSP1,TSP2,bFGF,VEGF and S-100β in patients with chronic subdural hematoma were relatively low 7 d after operation.Compared with the recurrent group,the levels of serum TSP1,TSP2,bFGF,VEGF and S-100β in the non-recurrent group were relatively low(P<0.05).Pearson correlation analysis showed that the levels of serum TSP1,TSP2,bFGF,VEGF and S-100β were negatively correlated with score of GCS(r=-0.655,-0.674,-0.711,-0.689,-0.705,P<0.05).Conclusion The levels of serum TSP1,TSP2,bFGF,VEGF and S-100β in patients with chronic subdural hematoma all decreased after drilling and drainage,and they were highly correlated with the degree and prognosis of brain injury.We could detect the changes of the above serological indexes in patients with chronic subdural hematoma in clinic,so as to judge the degree of brain injury in patients with chronic subdural hematoma in time.
subdural hematomachronicdrainage through drillingplatelet reactive protein 1platelet reactive protein 2basic fibroblast growth factorvascular endothelial growth factorcentral nervous system specific protein
万方数据
维普
