Correlation between NM23 gene expression and the growth site and lymph node metastasis of non-small cell lung cancer in 18F-FDG PET/CT
Objective To compare the differences in clinicopathologic features,18F-FDG PET/CT imaging features and survival time among non-small cell lung cancer with different NM23 gene expression profiles.Methods A total of 107 postoperative specimens of patients diagnosed with non-small cell lung cancer at the Affiliated Hospital of Xinjiang Medical University from January 2018 to December 2022 were selected as the research subjects.Immunohistochemistry was used to detect the expression of NM23,and the patients were divided into two groups:NM23 low expression group(≤++)with 64 cases and NM23 high expression group(>++)with 43 cases.The clinical and pathological characteristics,lymph node metastasis,tumor growth site under 18F-FDG PET/CT imaging,and survival period differences between the two groups were compared.Results The low-expression group and high-expression group of the NM23 gene showed no statistically significant differences in terms of gender,clinical stage,histological type,differentiation degree,smoking,PET/CT imaging location of tumor growth and survival time(P>0.05).There were statistically significant differences in both the primary tumor stage and the presence of lymph node metastasis on PET/CT imaging(P<0.05).Conclusion NM23 gene is supported as a tumor suppressor gene in non-small cell lung cancer patients in terms of T staging and lymph node metastasis.
non-small cell lung cancerNM23 geneclinicopathological featuresPET/CTgrowth sitesurvival time
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