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彩色多普勒超声与MRI联合诊断女性早期乳腺癌及分期的临床应用价值

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目的 探讨彩色多普勒超声与MRI联合诊断女性早期乳腺癌及分期的临床应用价值。方法 收集2021年8月~2023年10月于我院行乳腺常规检查的女性1525例,其中发现乳腺占位115例,所有患者均入院接受手术治疗,通过病理证实病灶的良、恶性,并对其临床及相关的影像资料进行分析。全部患者术前均行彩色多普勒超声和MRI检查,以病理结果为诊断的金标准,观察常规检查女性乳腺在行单一的彩色多普勒超声、单一的MRI以及二者联合的不同影像检查方法检测阳性的检出率,比较3种检查方法对乳腺癌早期诊断及其分期的应用价值。结果 115例行手术切除治疗并作病理学检查,共检查出病灶123个,其中67个为良性,56个为恶性;单一彩色多普勒超声诊断显示,良性病灶51个,误诊病灶16个;恶性病灶46个,漏诊病灶10个。单一MRI检查发现良性病灶61个,误诊病灶6个;恶性病灶53个,漏诊病灶3个。二者联合诊断发现良性病灶65个,误诊病灶2个;恶性病灶54个,漏诊病灶2个。单一MRI及彩色多普勒超声联合MRI诊断乳腺癌的准确性(93。50%,96。75%)高于单一彩色多普勒超声(78。86%,P<0。05);彩色多普勒超声联合MRI检查诊断乳腺癌的敏感度(96。43%)、特异度(97。01%)、阳性预测值(96。43%)以及阴性预测值(97。01%)高于彩色多普勒超声(82。14%、76。12%、74。19%、83。61%,P<0。05),MRI检查诊断的敏感度(94。64%)、特异度(91。04%)、阳性预测值(88。33%)、阴性预测值(96。83%)与彩色多普勒超声比较,差异无统计学意义(P>0。05);单一彩色多普勒超声、单一MRI与二者联合诊断在诊断乳腺癌不同分期方面的差异无统计学意义(P>0。05)。结论 单一的彩色多普勒超声和MRI在乳腺良、恶性病灶的诊断及鉴别诊断中均有一定的价值,而二者联合应用对于乳腺癌的早期诊断的准确性、敏感度及其分期上可以有效地得到提高。
Clinical application value of color Doppler ultrasonography and MRI combined in diagnosis and staging of female early breast cancer
Objective To evaluate the clinical value of color Doppler ultrasonography and MRI in diagnosis and staging of early breast cancer.Methods A total of 1525 cases of women who underwent routine mammary gland examination in our hospital from August 2021 to October 2023 were collected,and 115 cases of them were found to be occupied by mammary glands.All the patients were admitted to hospital for operation.The clinical and related imaging data were analyzed.All patients were preoperatively performed color Doppler ultrasound and MRI examination,the pathologic result is taken as the gold standard of diagnosis,the detection rate of positive detection in the routine examination of female mammary glands by single color Dopplerultrasound,single MRI and different image examination methods combined with the two is observed,To compare the value of three kinds of examination methods in early diagnosis and staging of breast cancer.Results 115 patients underwent surgical resection and pathologic examination.123 lesions were detected,of which 67 were benign and 56 were malignant.Single color doppler ultrasound showed that 51 benign lesions and 16 misdiagnosed lesions.There were 46 malignant lesions and 10 missed lesions.MRI alone showed 61 benign lesions and 6 misdiagnosed lesions.There were 53 malignant lesions and 3 missed lesions.65 benign lesions were found and 2 were misdiagnosed.There were 54 malignant lesions and 2 missed lesions.The accuracy of single MRI and color Doppler ultrasound combined with MRI(93.50%,96.75%)was higher than that of single color Doppler ultrasound(78.86%,P<0.05).The sensitivity(96.43%),specificity(97.01%),positive predicted label(96.43%),negative predicted label(97.01%)of color Doppler ultrasonography combined with MRI were higher than those of color Doppler ultrasonography(82.14%,76.12%,74.19%,83.61%).There was no significant difference in sensitivity(94.64%),specificity(91.04%),positive predictive value(88.33%)and negative predictive value(96.83%)between MRI and color Doppler ultrasound(P>0.05).There was no significant difference between single color Doppler ultrasound,single MRI and the combined diagnosis of the two in different stages of breast cancer(P>0.05).Conclusion Single color Doppler ultrasonography and MRI have certain value in the diagnosis and differential diagnosis of benign and malignant breast lesions,and their combined application can effectively improve the accuracy:sensitivity and staging of early diagnosis of breast cancer.

color Doppler ultrasonographyMRIbreast cancerearly diagnosisperiod of application

吴苑滨、徐晓伟、钟华成

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第九〇九医院(厦门大学附属东南医院)放射诊断科,福建 漳州 363000

彩色多普勒超声 MRI 乳腺癌 早期诊断 分期

2024

分子影像学杂志
南方医科大学

分子影像学杂志

CSTPCD
ISSN:1674-4500
年,卷(期):2024.47(4)
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