99mTc-c(RGD)2 SPECT/CT与18F-FDG PET/CT显像对肝泡型包虫病浸润带新生血管表达的相关性

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中文摘要：目的探讨99mTc肼基烟酰胺聚乙二醇双环RGD肽[99mTc-c(RGD)2]SPECT/CT与18氟-氟代脱氧葡萄糖(18F-FDG)PET/CT显像对肝泡型包虫病(HAE)增殖浸润带新生血管表达的相关性。方法采用前瞻性研究方法，收集2023年1月～2024年1月在新疆医科大学第一附属医院收治的34例HAE患者资料，所有患者均行全身18F-FDG PET/CT、腹部99mTc-c(RGD)2 SPECT/CT显像及手术治疗，对34例患者的41个HAE病灶组织行常规HE染色及CD34免疫组织化学染色，检测边缘带微血管密度(MVD)计数。分析HAE浸润带18F-FDG PET/CT显像的最大标准摄取值(SUVmax)及摄取比值(TBR)、99mTc-c(RGD)2 SPECT/CT显像靶非靶比值(T/NT)分别与MVD计数的相关性;比较HAE浸润带99mTc-c(RGD)2 SPECT/CT显像阳性(T/NT>1)及阴性(T/NT<1)两组间MVD计数的差异。结果 41个HAE病灶浸润带99mTc-c(RGD)2 SPECT/CT显像T/NT值与MVD计数两组间呈高度正相关性(r=0。823，P<0。01);18F-FDG PET/CT显像SUVmax值、TBR与MVD计数均无相关性(P>0。05)。HAE浸润带 99mTc-c(RGD)2 SPECT/CT显像阳性组17个与阴性组24个病灶MVD计数分别为89。00±9。87、43。08±18。36个/高倍视野，组间差异有统计学意义(P<0。05)。结论 HAE 99mTc-c(RGD)2 SPECT/CT显像RGD的摄取程度与HAE浸润带新生血管表达呈高度正相关，99mTc-c(RGD)2 SPECT/CT显像可间接反应HAE的侵袭性，可作为评价病灶侵袭性经济、无创的检查手段之一，并且可与18F-FDG PET/CT联合从HAE浸润带的新生血管表达及炎性活性两方面共同评价其生物学活性。

外文标题：Correlation between 99mTc-c(RGD)2 SPECT/CT and 18F-FDG PET/CT imaging on the expres-sion of neovascularization in the infiltration zone of hepatic alveolar echinococcosis

外文摘要：Objective To investigate the correlation between 99mTc-c(RGD)2 SPECT/CT and 18F-FDG PET/CT imaging on the expression of neovascularization in the infiltration zone of hepatic alveolar echinococcosis(HAE).Methods A prospective study was used to collect the data of 34 patients with HAE admitted to the First Affiliated Hospital of Xinjiang Medical University from January 2023 to January 2024.All patients underwent whole-body 18F-FDG PET/CT,abdominal 99mTc-c(RGD)2 SPECT/CT imaging and surgical treatment.Routine HE staining and CD34 immunohistochemical staining were performed on 41 HAE tissues,and microvascular density(MVD)counts in the infiltration zone were measured.Analyze the correlation between maximum standardized uptake value(SUVmax),tumor to background ratios(TBR),target to nontarget ratio(T/NT)and MVD counts in the infiltration zone of HAE,respectively;Compare the differences in MVD counts in the HAE infiltration zone between the 99mTc-c(RGD)2 SPECT/CT imaging positive(T/NT>1)and negative(T/NT<1)groups.Results In the 99mTc-c(RGD)2 SPECT/CT imaging,there was a high positive correlation(r=0.823,P<0.01)between the T/NT values and MVD counts in 41 HAE lesion infiltration zones;Compared with 18F-FDG PET/CT imaging,SUVmax value and TBR were not correlated with MVD count,respectively(P>0.05).The MVD counts in the 99mTc-c(RGD)2 SPECT/CT imaging positive group of 17 and negative group of 24 AE lesions were 89.00±9.87 and 43.08±18.36/high magnification field,and the difference between the two groups was statistically significant(P<0.05).Conclusion In the 99mTc-c(RGD)2 SPECT/CT imaging,the degree of RGD uptake is highly positively correlated with the amount of neovascularization in the infiltrating zone of HAE,99mTc-c(RGD)2 SPECT/CT imaging can indirectly reflect the invasiveness of liver AE,and can be used as one of the economic and non-invasive diagnostic methods to evaluate the invasiveness of lesions.It can also be combined with 18F-FDG PET/CT to evaluate its biological activity from both the expression of neovascularization and inflammatory activity in the infiltrating zone of HAE.

外文关键词：

echinococcosisintegrin αVβ3arginine glycine aspartic acidsingle photon computed tomographyfluorodeoxyglucosepositron emission tomographymicrovascular density

作者：

阿米娜·依布拉音、谢彬、秦永德、李肖红、李勇超

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作者单位：

新疆医科大学第一附属医院核医学科,新疆乌鲁木齐 830054

关键词：

包虫病整合素αvβ3 精氨酸-甘氨酸-天冬氨酸单光子计算机断层摄影术氟脱氧葡萄糖正电子发射断层显像术微血管密度

基金：

新疆维吾尔自治区自然科学基金

项目编号：

2022D01C241

出版年：

2024

DOI：

10.12122/j.issn.1674-4500.2024.05.02

分子影像学杂志

南方医科大学

分子影像学杂志

CSTPCD

ISSN：1674-4500

年,卷(期)：2024.47(5)