Correlation between 99mTc-c(RGD)2 SPECT/CT and 18F-FDG PET/CT imaging on the expres-sion of neovascularization in the infiltration zone of hepatic alveolar echinococcosis
Correlation between 99mTc-c(RGD)2 SPECT/CT and 18F-FDG PET/CT imaging on the expres-sion of neovascularization in the infiltration zone of hepatic alveolar echinococcosis
Objective To investigate the correlation between 99mTc-c(RGD)2 SPECT/CT and 18F-FDG PET/CT imaging on the expression of neovascularization in the infiltration zone of hepatic alveolar echinococcosis(HAE).Methods A prospective study was used to collect the data of 34 patients with HAE admitted to the First Affiliated Hospital of Xinjiang Medical University from January 2023 to January 2024.All patients underwent whole-body 18F-FDG PET/CT,abdominal 99mTc-c(RGD)2 SPECT/CT imaging and surgical treatment.Routine HE staining and CD34 immunohistochemical staining were performed on 41 HAE tissues,and microvascular density(MVD)counts in the infiltration zone were measured.Analyze the correlation between maximum standardized uptake value(SUVmax),tumor to background ratios(TBR),target to nontarget ratio(T/NT)and MVD counts in the infiltration zone of HAE,respectively;Compare the differences in MVD counts in the HAE infiltration zone between the 99mTc-c(RGD)2 SPECT/CT imaging positive(T/NT>1)and negative(T/NT<1)groups.Results In the 99mTc-c(RGD)2 SPECT/CT imaging,there was a high positive correlation(r=0.823,P<0.01)between the T/NT values and MVD counts in 41 HAE lesion infiltration zones;Compared with 18F-FDG PET/CT imaging,SUVmax value and TBR were not correlated with MVD count,respectively(P>0.05).The MVD counts in the 99mTc-c(RGD)2 SPECT/CT imaging positive group of 17 and negative group of 24 AE lesions were 89.00±9.87 and 43.08±18.36/high magnification field,and the difference between the two groups was statistically significant(P<0.05).Conclusion In the 99mTc-c(RGD)2 SPECT/CT imaging,the degree of RGD uptake is highly positively correlated with the amount of neovascularization in the infiltrating zone of HAE,99mTc-c(RGD)2 SPECT/CT imaging can indirectly reflect the invasiveness of liver AE,and can be used as one of the economic and non-invasive diagnostic methods to evaluate the invasiveness of lesions.It can also be combined with 18F-FDG PET/CT to evaluate its biological activity from both the expression of neovascularization and inflammatory activity in the infiltrating zone of HAE.
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