目的 应用沿血管周围间隙的扩散张量图像分析技术(DTI-ALPS)检测新诊断2型糖尿病(T2DM)患者脑胶质淋巴系统功能，探讨其与胰岛素抵抗指数(HOMA-IR)的相关性。方法 选取徐州医科大学附属医院2023年4～6月临床确诊的新诊断的T2DM患者30例作为新诊断T2DM组，同时选取本院体检的与新诊断T2DM组年龄、性别相匹配的健康人30例为对照组。收集受试者临床检验指标(糖化血红蛋白、空腹血糖、空腹胰岛素水平)，选取稳态模型作为评估胰岛素抵抗的指数，计算得出胰岛素抵抗HOMA-IR指数。采用3。0T核磁共振对60例受试者进行扫描，利用DTI计算ALPS指数，比较两组间的差异。采用Pearson相关性分析新诊断T2DM组HOMA-IR与ALPS指数之间的相关性。结果 新诊断T2DM组空腹血糖、空腹胰岛素、糖化血红蛋白、HOMA-IR高于正常对照组(P<0。05)。新诊断T2DM组ALPS指数下降(1。50±0。22 vs 1。31±0。18，P<0。001)，与HOMA-IR呈负相关(r=-0。622，P<0。001)。结论 DTI-ALPS技术可用于评估新诊断T2DM患者的胶质淋巴系统功能，其功能的下降与胰岛素抵抗密切相关。
Evaluating glymphatic system function and relationship with insulin resistance in newly diagnosed type 2 diabetes mellitus patients by diffusion tensor image analysis along the perivascular space
Objective To evaluate the glymphatic system function in patients with newly diagnosed type 2 diabetes mellitus(T2DM)by using diffusion tensor image analysis along the perivascular space(DTI-ALPS),and to explore the relationship with insulin resistance of homeostasis model(HOMA-IR).Methods A total of 30 patients with newly diagnosed T2DM,clinically diagnosed at the Affiliated Hospital of Xuzhou Medical University from April to June 2023,were selected as the newly diagnosed T2DM group.Additionally,30 healthy individuals who underwent physical examinations at the hospital and were matched with the newly diagnosed T2DM group in terms of age and gender were selected as the control group.The clinical indicators of the subjects were collected,including glycosylated hemoglobin(HbA1c)(%),fasting blood glucose(mmol/L),and fasting insulin(pmol/L)levels.The homeostasis model assessment(HOMA-IR)index of insulin resistance was calculated.Sixty subjects were scanned by a 3.0T MRI,and the ALPS index was calculated to compare the differences between the two groups.Pearson correlation was used to analyze the correlation between HOMA-IR and ALPS index in the newly diagnosed T2DM group.Results Significant differences were observed in fasting plasma glucose,fasting insulin,glycosylated hemoglobin,and HOMA-IR between the two groups(P<0.05).The ALPS index was significantly decreased in the newly diagnosed T2DM group(1.50±0.22 vs 1.31±0.18,P<0.001)and was negatively correlated with HOMA-IR(r=-0.622,P<0.001).Conclusion The DTI-ALPS index can be used to evaluate the glymphatic system function in patients with newly diagnosed T2DM,and the decline in glymphatic system function is related to insulin resistance.
type 2 diabetes mellitusdiffusion tensor image analysis along the perivascular spaceinsulin resistanceglymphatic system
万方数据
维普
