Application of high-frequency ultrasound combined with CT in the early diagnosis of papillary thyroid carcinoma and its predictive value for cervical lymph node metastasis
Objective To investigate the application of high-frequency ultrasound combined with CT in the early diagnosis of papillary thyroid carcinoma and its predictive value for cervical lymph node metastasis.Methods Clinical data of 120 patients with suspected papillary thyroid cancer admitted to the Fourth Affiliated Hospital of Xinjiang Medical University from January 2022 to July 2023 were retrospectively analyzed.All the patients underwent thyroidectomy and cervical lymph node dissection,and high-frequency ultrasound and CT examinations were performed.The pathological results were used as the gold standard to count the detection of papillary thyroid cancer and cervical lymph node metastasis by high-frequency ultrasound and CT alone and in combination,and the diagnostic value of high-frequency ultrasound and CT alone and in combination for papillary thyroid cancer and the predictive value for cervical lymph node metastasis were analyzed.Results Among the 120 patients with suspected papillary thyroid carcinoma,107(89.17%)were positive for papillary thyroid carcinoma and 13(10.83%)were negative;65(54.17%)had metastasis in the cervical lymph nodes and 55(45.83%)did not have metastasis.High-frequency ultrasound detected 72 true-positive and 9 true-negative papillary thyroid carcinomas;CT detected 74 true-positive and 10 true-negative;and combined examinations detected 89 true-positive and 11 true-negative cases.Using the pathologic results as the gold standard,high-frequency ultrasound detected 49 true-positive and 43 true-negative cervical lymph node metastases;CT detected 51 true-positive and 44 true-negative;and combined examination detected 61 true-positive and 52 true-negative.ROC curve analysis showed that the sensitivity,accuracy,and AUC of the combined high-frequency ultrasound and CT examination were higher than those of the high-frequency ultrasound and CT single examination for diagnosing papillary thyroid carcinoma(P＜0.05);the sensitivity,specificity,positive predictive value,negative predictive value,accuracy,AUCs of the combined high-frequency ultrasound and CT examination for predicting cervical lymph node metastasis were higher than those of the high-frequency ultrasound,CT single examination(P＜0.05).Conclusion The value of high-frequency ultrasound combined with CT for early diagnosis of papillary thyroid cancer was high,and it could predict the metastasis of the patient's cervical lymph nodes,and the combined examination of the two was better than the examination alone.
papillary thyroid cancerhigh-frequency ultrasoundcomputed tomographylymph node metastasispredictive value
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