Diagnostic value of CT imaging in hepatic fibrosis of chronic hepatitis B patients
Objective To evaluate the diagnostic value of CT imagomics in hepatic fibrosis in patients with chronic hepatitis B(CHB).Methods A total of 210 patients with CHB admitted to Xinjiang Uygur Autonomous Region People's Hospital from January to October in 2023 were selected as the study subjects.Patients were divided into non-fibrosis group(n=137)and fibrosis group(n=73).All patients underwent CT plain scan+enhanced scan.Shukun Radiomics V 94 software was used to extract different CT imagomics features from the region of interest of each CT image,including texture feature,shape feature,filter feature,density feature,etc.The enrolled patients were divided into training set(n=147)and validation set(n=63),and the diagnostic model of liver fibrosis in CHB patients was screened and established by LASSO and Logistic regression analysis.The performance of the model was evaluated using the ROC curve.Results After LASSO screening,23 of the 1227 extracted quantitative image features were retained to construct the diagnostic model of liver fibrosis in CHB patients.The AUC,accuracy,sensitivity,and specificity of the training set were 0.851,0.789,0.792,and 0.735,respectively;The AUC,accuracy,sensitivity,and specificity of the validation set were 0.774,0.733,0.751,and 0.703,respectively.Conclusion The CT image-omics features show clinical significance in the assessment of liver fibrosis in patients with CHB.
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