Clinical value of B1-corrected T1 mapping in the diagnosis of benign and malignant lung nodules and pathological classification
Objective To explore the clinical value of B1-corrected T1 mapping in the diagnosis of benign and malignant lung nodules and the identification of the pathological types of lung cancer.Methods Fifty-four patients with a total of 57 lung nodules underwent chest B1-corrected T1 mapping were collected in Yancheng No.1 People's Hospital from August 2020 to July 2022,including 17 cases of benign and 40 cases of malignant lung nodules.The native T1 values of lesions were manually measured by two independent radiologists(observers A and B).The intra-and inter-observer reproducibility were evaluated with intraclass correlation coefficients.The differences of T1 values between the benign and malignant lung nodules were compared.ROC curves were identified the best threshold value for distinguishing the benign and malignant lung nodules.The native T1 values among different pathological types of lung cancer were compared by one-way analysis of variance.Results The native T1 values of lung nodules showed good reproducibility both within and between observers(intraclass correlation coefficients=0.977,0.953).The native T1 values of benign pulmonary nodules measured by observers A and B were 1615.98±337.28 ms and 1618.52±362.82 ms,respectively.The native T1 values of malignant pulmonary nodules measured by observers A and B were 1376.87±262.50 ms and 1392.51±301.30 ms,respectively.The native T1 values of benign lung nodules was significantly higher than those of malignant lung nodules(P=0.006 and 0.020).ROC curve analysis showed that when the threshold value was 1350.33 ms,the sensitivity and specificity of the diagnosis of malignant pulmonary nodules were 53.66%and 87.50%,and the AUC was 0.720(95%CI:0.586-0.831).The native T1 values were different among adenocarcinoma,squamous cell carcinoma and small-cell lung cancer(observer A and B:P=0.009 and P=0.010).The native T1 values of small-cell lung cancer were significantly higher than those of adenocarcinoma and squamous cell carcinoma(P=0.003 and P=0.049),but there was no statistically significant difference between adenocarcinoma and squamous cell carcinoma(P=0.944 and P=0.774).Conclusion B1-corrected T1 mapping is a rapid,non-invasive quantitative imaging technique with a good repeatability that can be used to distinguish between benign and malignant lung nodules and identify the pathological types of lung cancer.
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