Advances in molecular biology and imaging of artificial meniscal scaffolds
The meniscus,an important structure for maintaining the biomechanical balance of the knee,has an extremely limited regenerative capacity.In cases of irreparable meniscus injuries,both conventional meniscectomy and meniscus implantation have their limitations.Therefore,artificial meniscus scaffolds based on tissue engineering appear to be promising.However,many challenges such as the complex structure of meniscal anisotropy,the difficult regeneration process and specific biomechanical properties remain barriers to clinical application.The aim of this review is to summarize the progress of molecular biology research on artificial meniscal scaffolds and the application of imaging tools in meniscal transplantation,starting from the anatomy and physiology of the meniscus,and in conjunction with the current therapeutic strategies for meniscus injuries,to consider the prospects for their application in meniscal tissue engineering and the clinical translational challenges they face.
国家科技期刊平台
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