Research progress of novel gastrin releasing peptide receptor-targeted PET molecular probes for tumor imaging
Gastrin-releasing peptide receptor(GRPR)is a G protein-coupled receptor belonging to the bombesin receptor family,mainly distributed throughout the gastrointestinal tract and central nervous system,exerting biological functions by binding with its ligand gastrin-releasing peptide.Recent studies have found that GRPR is overexpressed in many malignant tumors and is involved in the development of malignancies such as breast cancer,prostate cancer,lung cancer,pancreatic cancer,and medulloblastoma.Positron emission tomography(PET)is a medical imaging technique that provides images by detecting the distribution and concentration of radiolabeled substances within the body,offering more comprehensive and accurate diagnostic information.Existing research has shown that GRPR-targeted PET imaging plays a significant role in the diagnosis,treatment monitoring,and prognosis assessment of various malignant tumors.Therefore,the development of highly specific and high-affinity GRPR probes is of great significance for the diagnosis and treatment of tumors.This article provides a review of the types of novel GRPR-targeted PET molecular probes reported and their applications in tumor imaging,aiming to offer new ideas and directions for the research and clinical translation of GRPR-targeted PET molecular probes.
国家科技期刊平台
NSTL
万方数据
