Objective To study the effects of glycemic-related indexes and glycemic control on MRI white matter hyperintensity(WMH)volume in patients with type 2 diabetes mellitus(T2DM).Methods A retrospective case-control study was used.A total of 149 T2DM patients admitted to Xuzhou Central Hospital from July 2022 to December 2023 were enrolled in this study,and they were divided into the glycemic control attainment group(HbA1c<7%,n=66)and the non-attainment group(HbA1c≥7%,n=83)according to the level of glycosylated hemoglobin(HbA1c),and the craniocerebral MRI and related hematological examination results completed during hospitalization were collected from all patients.ITK-SNAP software was used to outline the patients'WMH and derive the volume.Multiple linear regression analysis was used to analyze the correlation between glycemic control and WMH volume in T2DM patients.Results The HbA1c level of T2DM patients was correlated with WMH volume.WMH volume,duration of T2DM,hypertension,fasting blood glucose,2 h postprandial blood glucose,fasting insulin,and triglyceride in the glycemic control non-attainment group were all higher than those in the attainment group(P<0.05).The multiple linear regression analysis after correcting for age,gender and other risk factors suggested that there was a linear relationship between WMH volume and glycemic control in T2DM patients.Conclusion Glycemic control in T2DM patients is an important influence on WMH volume,and those with poorer glycemic control are susceptible to higher WMH volumes,which provides a basis for intensifying preventive strategies and monitoring of early treatment in individuals at risk for WMH-related morbidity.
关键词
2型糖尿病/血糖控制/磁共振成像/脑白质高信号/相关性
Key words
type 2 diabetes mellitus/glycemic control/magnetic resonance imaging/white matter hyperintensity/correlation
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