Research progress of molecular imaging of synovial neovascularization evaluated by RGD in radionuclide imaging for rheumatoid arthritis
The formation of synovial pannus is one of the important pathological features of rheumatoid arthritis,which triggers articular cartilage and bone injury,leading to joint remodeling,eventual joint deformity and dysfunction.In this process,new angiogenesis plays a crucial role in the invasion and destruction of synovial pannus,enhancing its aggressiveness and accelerating cartilage and bone injury.Neovascularization occurs early in rheumatoid arthritis and persists throughout the course of the disease.Integrin αvβ3 is highly expressed in angiogenesis and has a high affinity for arginine-glycine-aspartate(RGD).Exploring imaging techniques that target angiogenesis in rheumatoid arthritis is significant for early detection,assessment of disease activity,selection of targeted treatment,and prognosis assessment.This review classifies PET and SPECT imaging tracers based on their targeting of αvβ3 integrins,lists different types of RGD peptide subunit radiotracers,compares the advantages and disadvantages of different radionuclide markers for diagnosing rheumatoid arthritis based on RGD subunits.
万方数据
维普
