The clinical application of multimodal ultrasound features in predicting Luminal subtype invasive ductal carcinoma
Objective To investigate the clinical value of predicting Luminal subtype invasive ductal carcinoma(IDC)based on multimodal ultrasound features.Methods Eighty-five patients with Luminal IDC diagnosed by pathology from June 2021 to December 2023 in Inner Mongolia Autonomous Region People's Hospital were selected,including 38 cases in the Luminal A(LA)group and 47 cases in the Luminal B(LB)group.Differences in conventional ultrasound,elastography and contrast-enhanced ultrasound characteristics of the lesions in the two groups were compared;characteristic parameters with statistically significant differences were subjected to single and multifactorial logistic regression analyses with the LB type,and a logistic regression model was established;and the diagnostic efficacy in predicting the LB type of IDC was analyzed by plotting the ROC curves.Results Compared with the LA group,the LB group had a larger maximum diameter of the lesion,percentage of blood-rich type,maximum Young's modulus inside the lesion(Emax),average peritumour Young's modulus(Emean shell-2.0),maximum Young's modulus(Emax shell-2.0),percentage of contrast perfusion defect,peak intensity(PI),area under the curve(AUC),and mean transit time;arrival time(AT)and percentage of peritumoural hyperechoic halo were smaller,and all the differences were statistically significant(P＜0.05).Multifactorial regression analysis showed that AT and peritumoural hyperechoic halo were independent protective factors for the prediction of LB,and PI,perfusion defect and Emax shell-2.0 were independent risk factors for the prediction of LB.A logistic regression model was constructed to predict LB-type IDC:Logit(P)=-9.868-2.004×peritumoural hyperechoic halo+2.896×perfusion defect-0.399×AT+0.379×PI+0.030×Emax shell-2.0.ROC curve analysis showed that the logistic regression model had the highest diagnostic efficacy,with an area under the curve of 0.945 with a sensitivity and specificity of 89.4%and 89.5%,respectively.Conclusion The multimodal ultrasound characteristics of different IDC subtypes have certain differences,and the logistic regression model based on multimodal ultrasound characteristics has value in predicting Luminal subtypes,which can provide an important reference for individualised diagnosis and treatment of IDC of different subtypes.
万方数据
维普
