Reduced gray matter volume in patients with end-stage renal disease before first dialysis can provide imaging markers for cognitive function
Objective To systematically analyze the changes of gray matter volume in end-stage renal disease(ESRD)patients prior to first dialysis using voxel-based morphometry,and to explore the relationship between these changes and global cognitive function,executive function and working memory function.Methods Sixty-two ESRD patients were enrolled at the hospital from February 2022 to January 2024 before their first hemodialysis,alongside 37 healthy controls.High-resolution 3D T1 structural imaging and neuropsychological tests(including assessments of global cognitive function,executive function,and working memory)were conducted.Voxel-based morphometry method was used to analyze differences in gray matter volume between the two groups,and Pearson correlation analysis was performed to examine the relationship between gray matter volume in different brain regions and test results,after adjusting for gender,age,and education level.Results Compared with the control group,the gray matter volume in the left postcentral gyrus,bilateral superior temporal gyrus,bilateral precentral gyrus,right temporopolar middle temporal gyrus,left rectus gyrus,left middle cingulate gyrus,bilateral orbital superior frontal gyrus,left middle temporal gyrus,bilateral hippocampus,and left fusiform gyrus were significantly reduced in the ESRD group(P＜0.001,corrected for FWE).In the ESRD group,the volumes of the left postcentral gyrus,left anterior central gyrus,left rectus gyrus,left middle cingulate gyrus,left orbitofrontal gyrus,left middle temporal gyrus,left superior temporal gyrus,and left hippocampus were positively correlated with Montreal cognitive assessment scores(P＜0.05).Conversely,the volumes of the right temporopolar middle temporal gyrus,left middle cingulate gyrus,left fusiform gyrus,and left superior temporal gyrus were negatively correlated with trail making test A scores(P＜0.05).Additionally,the volumes of the left rectus gyrus and the left orbital superior frontal gyrus were negatively correlated with 2-back reaction times(P＜0.05).Conclusion There is a general decrease in gray matter volume in ESRD patients,which is closely related to overall cognitive function,executive function,and working memory.These findings can provide imaging markers for assessing cognitive dysfunction in ESRD patients.
end-stage renal diseasemorphological measurement method based on voxelsgray matter volumeoverall cognitive functionexecutive functionworking memory function
万方数据
维普
