The combined application of multiple quantitative values of synthetic magnetic resonance imaging can improve the diagnostic accuracy of sjogren's syndrome
Objective To explore the feasibility and clinical application value of MAGiC technique in the diagnosis of Sjogren's syndrome(SS).Methods A total of thirty-six SS patients from the Affiliated Hospital of Yangzhou University from February to October 2023 were selected as the SS group,and thirty-eight healthy volunteers from the same period were selected as the control group(HC group).T1WI,T2WI and MAGiC scanning were performed on bilateral parotid glands of the two groups,respectively.After post-processing of MAGiC images,three sets of quantitative sequences T1,T2,proton density(PD)mapping were generated.The obtained T1,T2 and PD values of the bilateral parotid glands were measured by two physicians,and intra-group correlation coefficient(ICC)was used to evaluate inter-observer and intra-observer consistency;the correlation of quan titative values of MAGiC in bilateral parotid glands was compared by Pearson or Spearman test;and the independent samples t test or Wilcoxon rank sum test was used to analysis the differences in quantitative values of MAGiC between the bilateral parotid gland SS group and HC group.ROC curves were plotted for counting data with statistically significant differences in MAGiC quantitative values,and Z-test was used to compare the area under the curve.Results The results of consistency analysis showed that both T2 and PD values of the bilateral parotid gland had ICC＞0.800,while T1 values of the bilateral parotid gland were lower(ICC＞0.700).Correlation analysis showed that the quantitative values of MAGiC were highly correlated between the two groups(r＞0.8).The analysis results between the two groups showed that T1 and T2 values were statistically significant(P＜0.001),while PD values were not statistically significant(P＞0.05).The accuracy(84.35%)and area under the curve(0.88)of the combination of MAGiC T1 and T2 values were the highest,and the difference with T1 values was statistically significant(P=0.026).Conclusion MAGiC technology can quantitatively evaluate SS parotid gland lesions,and the combined application of multiple quantitative values of MAGIC technology can improve the diagnostic accuracy.
万方数据
维普
