Echocardiography combined with serum angiotensin-converting enzyme levels can be used as a potential biological indicator to evaluate cardiac function in hypertensive patients during pregnancy
Objective To investigate the value of echocardiography combined with serum angiotensin-converting enzyme(ACE)in the diagnosis of gestational hypertension(HIP)and its correlation with cardiac function.Methods Fifty patients with HIP who were treated in our hospital from March 2021 to March 2024 were included as the study group,and another 50 healthy subjects who underwent physical examination in our hospital during the same period were selected as the control group.The echocardiographic results,serum ACE levels and cardiac function indexes of HIP patients in the study group and the control group were determined.The correlation between echocardiography,serum ACE and cardiac function index was analyzed by Pearson.ROC curve analysis of echocardiography,serum ACE alone and combined diagnostic value of HIP.Results The level of early diastolic filling peak velocity/late diastolic filling peak velocity(E/A)and early diastolic rapid filling fraction(RFF)in the study group were lower than those in the control group(P＜0.05),left ventricular ejection fraction(LVEF),ACE level,troponin T(cTnT)level and plasma brain natriuretic peptide(BNP)level were higher than those of control group(P＜0.05);Pearson analysis showed that E/A and RFF in HIP patients were negatively correlated with cTnT and BNP(P＜0.05),while LVEF and ACE were positively correlated with cTnT and BNP(P＜0.05).ROC curve analysis showed that the AUC value of ACE in diagnosis of gestational hypertension was 0.619,and the AUC value of E/A,RFF,LVEF and the combination of the four patients in diagnosis of gestational hypertension was 0.700,0.706,0.793,0.880,respectively.Conclusion Echocardiography combined with serum ACE level can be used as a potential biological index to evaluate cardiac function in HIP patients.
serum angiotensin converting enzymeechocardiographyhypertension during pregnancycardiac function
万方数据
维普
